|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
With respect to the TLR2 rs4696480 polymorphism, significant association was detected between asthma susceptibility and TLR2 rs4696480 polymorphism under dominant model (OR = 2.455, 95% CI = 1.235-4.88, P = .01) and codominant 3 model (OR = 2.776, 95% CI = 1.199-6.427, = 0.017).
|
28514297 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Wherease some previous studies indicated TLRs and their polymorphisms might have some role in asthma incidence and features, our data demonstrated that TLR2 Arg753Gln and TLR4 Asp299Gly gene variants were not risk factors for asthma or its features in Iranian patients.
|
25530138 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We observed that children who were heterozygous or homozygous for both the CD14/-159T and TLR2/-16934A alleles had a 4-fold lower risk for asthma than children who were carriers of the T allele of CD14 but non-carriers of the A allele of TLR2, and an almost 3-fold lower risk for asthma when compared to all other groups.
|
31403268 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that polymorphism of the TLR2 subfamily may be associated with prevalence of post-bronchiolitic asthma and/or atopy.
|
24445834 |
2014 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of TLR2 and TLR4 on macrophages with increased sensitivity to hyaluronan fragments suggests a novel proinflammatory mechanism by which persistence of hyaluronan fragments could contribute to chronic inflammation and airway remodeling in asthma.
|
21570715 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Twenty-four single nucleotide polymorphisms (SNPs) in CD14, Toll-like receptor 4 (TLR4), TLR2, MD2 and MyD88 were genotyped in 408 agricultural workers with spirometry and questionnaire data on asthma symptoms available.
|
21389010 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study potential associations between single nucleotide polymorphisms (SNPs) in CD14, Toll-like receptor 2 (TLR2), and TLR4 genes, and atopy and new-onset asthma in young farmers.
|
17877764 |
2007 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate main effects and gene-gene interactions of haplotype tagging single nucleotide polymorphisms of genes involved in regulatory T-cell function-IL6, IL6R, IL10, heme-oxygenase 1 (HMOX1), IL2, Toll-like receptor 2 (TLR2), TGFB1, TGF-beta receptor (TGFBR)-1, TGFBR2, IL2RA, and forkhead box protein 3 (FOXP3)-in relation to atopy and asthma.
|
20599261 |
2010 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TLR4 and TLR2 were reduced in total PBMC from asthmatics in comparison to PBMC from controls.
|
25722071 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This suggests a protective role for TLR2 activation and MMP-9 release in the context of experimentally induced asthma in mice.
|
19667087 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combined results show that rs3804099 in TLR2 and rs4986791 in TLR4 were significantly associated with asthma risk.
|
28858111 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these data implicated that ABCA1 suppressed PDGF-induced proliferation, migration, and contraction in rat ASMCs at least partly through TLR2/NF-κB/NFATc1 signaling, which might offer hope for the future treatment of airway remodeling in asthma.
|
29775222 |
2018 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sputum TLR2 mRNA expression was up-regulated in both acute and stable asthma compared with healthy controls and decreased 4-6 weeks after acute exacerbation.
|
21129050 |
2011 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Short-term exposure to A. fumigatus could down-regulate the expression of GCR, aggravate airway hyper-responsiveness and increase the level of TLR2 in rats with asthma.
|
28696809 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum IP-10 levels showed a significant negative correlation with age (p=0.009), TLR2 (p=0.05) and spirometric indices (p=0.002) in all asthmatics and a significant positive correlation with parameters of asthma attack severity (p=0.03) in acute asthma group.
|
27955890 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Resting and lipopolysaccharide (LPS)-stimulated circulating neutrophils had lower levels of TLR2 and IL-1beta gene expression in asthma, but were otherwise similar to healthy controls.
|
19842845 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Our results suggest that genetic variation in TLR2 is a major determinant of the susceptibility to asthma and allergies in children of farmers.
|
15007351 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that genetic variation in TLR2 is a major determinant of the susceptibility to asthma and allergies in children of farmers.
|
15007351 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that a genetic variant in the TLR2 subfamily may play a role in susceptibility to asthma.
|
20815312 |
2010 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interaction between ITGB3 SNPs and TLR2/+596, which was previously shown to be associated with asthma, was studied.
|
21570717 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our study demonstrates a lack of association of TLR2 and TLR4 polymorphisms with asthma and allergic rhinitis but suggests significant association between these genetic variants and the disease severity.
|
22402138 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, recent results indicate that the TLR-2 → NLRP3 → caspase-1 → IL-18 axis is critical to H. pylori-specific immune regulation conferring protection against allergen-induced asthma and inflammatory bowel disease in murine models.
|
27460807 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
HE staining showed that the infiltration degree of inflammatory cells in perivascular tissues in TLR2-/- asthma group was reduced compared with that in C57BL/6 asthma group.
|
29863259 |
2018 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, TLR2 expression at the protein and mRNA levels was upregulated in cord blood basophils from neonates born to mothers with asthma following stimulation with PGN but not Df.
|
21438704 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of toll-like receptor (TLR) 2 subfamily genes, including genes encoding TLR1, TLR2, TLR6 and TLR10, have been connected to allergy and asthma.
|
24112285 |
2013 |